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MYP_074438
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Basic Information
Brevinin-1V
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C124H209N29O28S2
Standard
Sequence
FLPLIASVAANLVPKIFCKITKKC
Physicochemical Analysis
2618.29 Da
9.70
3.74
3.50
0.1557
1.06
0.69
0.31
18.56
134.17
0.0833
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
902.67
-3.68
32.0
34.0
85.0
183.0
4.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0144133 VERIFIED: YES
Provenance & Taxonomy
Odorrana tiannanensis [Animal]
Brevinin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0154537 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterococcus faecium 091299
19 μM
MIC
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
RECORD: Rec_0184536 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal Hemolytic
human erythrocytes
75 μM
LC50
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
RECORD: Rec_0187889 VERIFIED: NO
Provenance & Taxonomy
Rana versabilis [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://camp.bicnirrh.res.in/seqDisp.php?id=CAMPSQ1801
RECORD: Rec_0226005 VERIFIED: YES
Provenance & Taxonomy
Odorrana versabilis [Animal]
Brevinin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Bacillus licheniformis X39
37.5 μM
MIC
PMID16139929;22450466 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16139929/
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