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MYP_074415
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Basic Information
35[11E](derived from HCV C5A)
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Antiviral ▸ Virucidal activity
Standard
18 amino acids
C111H157N25O31
Standard
Sequence
SWLRDIWDWIEEVLSDFK
Physicochemical Analysis
2337.58 Da
4.10
-3.53
-3.75
-0.1962
-0.37
0.80
0.06
56.98
102.78
0.2222
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
920.27
-2.57
33.0
28.0
74.0
167.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0005674 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Hepatitis C virus(HCV):inhibition of HCV infection in Huh-7
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0007383 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
5
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0022781 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0153427 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
cells
13 μM
IC50
PaperA virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-3093. doi: 10.1073/pnas.0712380105. PMID: 18287023. PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
RECORD: Rec_0188386 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
Hepatitis C virus HCV JFH-1
PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/
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