Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length53 amino acids

Chemical FormulaC246H398N70O83S5

DescriptionStandard

        MKNNNKICQDALESLQELKLEEVDELLGGAGHGVNTISAECRWNSLQAIFSCC
    

Molecular Weight5824.54 Da

Isoelectric Point (pI)4.59

Net Charge (pH 7.0)-4.44

Net Charge (pH 7.4) -4.78

Charge Density (pH 7.0) -0.0837

GRAVY Index-0.22

Hydrophobic Moment 0.58

Boman Index0.02

Instability Index59.32

Aliphatic Index 92.08

Aromaticity 0.0377

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5750.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2505.22

LogP -28.30

H-bond Donors 87.0

H-bond Acceptors 85.0

Rotatable Bonds 202.0

Heavy Atoms 404.0

Ring Count 4.0

Amide Bonds 60.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0020121 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus macedonicus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic Non-ribosomal

TargetGram-positive bacteria

MethodQualitative functional evidence

RECORD: Rec_0054022 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus agalactiae [Bacterium]

FamilyLantibiotic

Structure & Mods

Configthioether-cyclized lantibiotic scaffold [Cyclic]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLanthionine/methyllanthionine-type thioether crosslinks are implied by the lantibiotic annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive

TargetGram-positive bacteria

RECORD: Rec_0106498 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus suis [Bacterium]

FamilyLantibiotic

Structure & Mods

Configthioether-cyclized lantibiotic scaffold [Cyclic]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLanthionine/methyllanthionine-type thioether crosslinks are implied by the lantibiotic annotation

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive

TargetGram-positive bacteria

RECORD: Rec_0410562 VERIFIED: NO

Provenance & Taxonomy

OrganismStreptococcus gallolyticus [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence