Peptide Database

Peptide NameUnnamed

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC96H143N17O20

DescriptionStandard

        SFAIKWEYVLLLFLL
    

Molecular Weight1855.26 Da

Isoelectric Point (pI)5.72

Net Charge (pH 7.0)-0.54

Net Charge (pH 7.4) -0.75

Charge Density (pH 7.0) -0.0359

GRAVY Index1.65

Hydrophobic Moment 0.19

Boman Index0.63

Instability Index3.67

Aliphatic Index 182.00

Aromaticity 0.2667

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 590.29

LogP 3.28

H-bond Donors 21.0

H-bond Acceptors 20.0

Rotatable Bonds 58.0

Heavy Atoms 133.0

Ring Count 5.0

Amide Bonds 14.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0261020 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configsynthetic linear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HCV Entry inhibition

TargetHepatitis C virus(HCVpp) | hepatoma cells

Activity50 μM

Method% inhibition

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperA peptide derived from hepatitis C virus E2 envelope protein inhibits a post-binding step in HCV entry. | Liu R, Tewari M, Kong R, Zhang R, Ingravallo P, Ralston R. | Antiviral Res. 2010 May;86(2):172-9. | DOI:10.1016/j.antiviral.2010.02.316 | PMID:20156485 PMID20156485 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20156485/

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