Peptide Database

Peptide NamePembrolizumab

Function Ontology

Anticancer

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Standard StatusStandard

Sequence Length447 amino acids

Chemical FormulaC2201H3384N578O681S18

DescriptionStandard

        QVQLVQSGVEVKKPGASVKVSCKASGYTFTNYYMYWVRQAPGQGLEWMGGINPSNGGTNFNEKFKNRVTLTTDSSTTTAYMELKSLQFDDTAVYYCARRDYRFDMGFDYWGQGTTVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK
    

Molecular Weight49415.05 Da

Isoelectric Point (pI)7.95

Net Charge (pH 7.0)2.30

Net Charge (pH 7.4) 1.45

Charge Density (pH 7.0) 0.0051

GRAVY Index-0.45

Hydrophobic Moment 0.60

Boman Index-0.00

Instability Index44.89

Aliphatic Index 64.18

Aromaticity 0.1051

Extinction Coeff. Reduced 75290.00

Extinction Coeff. Oxidized 75915.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0393219 VERIFIED: NO

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyMonoclonal antibody

Tax ID10090

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anticancer Immunomodulatory Immuno-oncology

Half-Life22 days.