Peptide Database

Peptide NamePotassium channel toxin OdK1

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Membrane / Ion-channel modulation ▸ Ion channel modulation

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Toxic

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length29 amino acids

Chemical FormulaC123H203N39O48S6

DescriptionStandard

        VSCEDCPEHCSTQKARAKCDNDKCVCESV
    

Molecular Weight3188.55 Da

Isoelectric Point (pI)4.95

Net Charge (pH 7.0)-2.23

Net Charge (pH 7.4) -2.59

Charge Density (pH 7.0) -0.0769

GRAVY Index-0.72

Hydrophobic Moment 0.32

Boman Index-0.28

Instability Index42.73

Aliphatic Index 36.90

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 375.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1428.87

LogP -20.80

H-bond Donors 54.0

H-bond Acceptors 53.0

Rotatable Bonds 107.0

Heavy Atoms 216.0

Ring Count 2.0

Amide Bonds 30.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0017218 VERIFIED: YES

Provenance & Taxonomy

OrganismOdonthobuthus doriae [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Toxin Ion Channel Blocker Potassium Channel Blocker

TargetKv1

Activity0.183 ± 0.003 μM

MethodIC50

RECORD: Rec_0236393 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Toxic Cytotoxic