Peptide Database

Peptide NameGambicin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiparasitic ▸ Antimalarial

Antiparasitic ▸ General antiparasitic ▸ Antiparasitic

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC292H447N83O87S9

DescriptionStandard

        MVFAYAPTCARCKSIGARYCGYGYLNRKGVSCDGQTTINSCEDCKRKFGRCSDGFITECFF
    

Molecular Weight6800.76 Da

Isoelectric Point (pI)8.69

Net Charge (pH 7.0)3.42

Net Charge (pH 7.4) 3.07

Charge Density (pH 7.0) 0.0561

GRAVY Index-0.21

Hydrophobic Moment 0.73

Boman Index-0.05

Instability Index41.39

Aliphatic Index 41.64

Aromaticity 0.1475

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6460.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2772.64

LogP -32.32

H-bond Donors 108.0

H-bond Acceptors 100.0

Rotatable Bonds 222.0

Heavy Atoms 471.0

Ring Count 10.0

Amide Bonds 63.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0086537 VERIFIED: YES

Provenance & Taxonomy

OrganismAnopheles gambiae [Animal]

FamilyInsect antimicrobial peptide

Tax ID7165

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Antiparasitic Antimalarial

TargetPlasmodium berghei

Activity100 μM

MethodPercent inhibition; Microscopy (calcein AM and ethidium homodimer staining)

RECORD: Rec_0120057 VERIFIED: YES

Provenance & Taxonomy

OrganismAnopheles gambiae [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetEscherichia coli

RECORD: Rec_0153497 VERIFIED: YES

Provenance & Taxonomy

OrganismAnopheles gambiae [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetMicrococcus luteus

RECORD: Rec_0216882 VERIFIED: YES

Provenance & Taxonomy

OrganismAnopheles gambiae [Animal]

FamilyGambicin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiparasitic