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MYP_074129
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Basic Information
Cathelicidin 4, buCATHL4E
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
14 amino acids
C96H136N22O15
Standard
Sequence
AIPWIWIWWLLRKG
Physicochemical Analysis
1838.25 Da
11.00
1.79
1.61
0.1282
0.64
0.36
0.48
21.68
146.43
0.2857
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
583.91
4.38
22.0
17.0
52.0
133.0
9.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0323859 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0339521 VERIFIED: YES
Provenance & Taxonomy
Bubalus bubalis [Animal]
Cathelicidin
89462
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 14028
1.5 μM
MIC
PMID26675301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26675301/
RECORD: Rec_0385125 VERIFIED: YES
Provenance & Taxonomy
Bubalus bubalis [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus NCDC-0111
0.4 μM
MIC
PaperDiversity, Antimicrobial Action and Structure-Activity Relationship of Buffalo Cathelicidins.
RECORD: Rec_0411448 VERIFIED: YES
Provenance & Taxonomy
Bubalus bubalis [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Salmonella Typhimurium ATCC-14028
1.5 μM
MIC
PaperDiversity, Antimicrobial Action and Structure-Activity Relationship of Buffalo Cathelicidins.
RECORD: Rec_0418428 VERIFIED: YES
Provenance & Taxonomy
Bubalus bubalis [Animal]
Cathelicidin
89462
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa NCDC 0105
6 μM
MIC
PMID26675301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26675301/
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