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MYP_073876
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Basic Information
Dermaseptin-5.1TR
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C118H193N31O33S2
Standard
Sequence
GLWSKIKEAAKTAGKAAMGFVNEMV
Physicochemical Analysis
2638.11 Da
9.53
1.76
1.55
0.0705
0.10
0.64
0.16
8.88
74.40
0.0800
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1039.74
-8.60
36.0
37.0
91.0
184.0
3.0
25.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0000113 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa trinitatis [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
PMID29980138 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29980138/
RECORD: Rec_0001703 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Staphylococcus aureus
Evidence URLhttps://www.uniprot.org/uniprotkb/P84925/entry
RECORD: Rec_0009777 VERIFIED: NO
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Cytolytic Hemolytic
Pseudomonas aeruginosa
Evidence URLhttps://www.uniprot.org/uniprotkb/P84925/entry
RECORD: Rec_0027176 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Enterococcus faecalis
Evidence URLhttps://dramp.cpu-bioinfor.org/browse/All_Information.php?dataset=General&id=DRAMP01677
RECORD: Rec_0052869 VERIFIED: YES
Provenance & Taxonomy
Phyllomedusa tarsius [Animal]
Dermaseptin
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
PaperS. Charpentier et al. / The Journal of Biological Chemistry 273 (1998) 14690-14697. Structure, synthesis, and molecular cloning of dermaseptins B, a family of skin peptide antibiotics Evidence URLhttps://www.uniprot.org/uniprotkb/P84925/entry
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