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MYP_073852
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Basic Information
Gaegurin-RN4
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Immunology ▸ Adverse immune reactivity ▸ Histamine-release modulation
Immunology ▸ Innate immune modulation ▸ Mast cell modulation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
24 amino acids
C121H204N28O27S2
Standard
Sequence
FVGPVLKIAAGILPTAICKIYKKC
Physicochemical Analysis
2547.22 Da
9.60
3.74
3.50
0.1556
1.07
0.58
0.37
15.97
134.17
0.0833
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
859.58
-2.58
31.0
33.0
82.0
178.0
4.0
23.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0367164 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Staphylococcus aureus ATCC25923
1.17 μg/mL
MIC
PaperPeptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata. Genomics. 2010 Jan;95(1):66-71. doi: 10.1016/j.ygeno.2009.09.004. PMID: 19778602. PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0405927 VERIFIED: YES
Provenance & Taxonomy
Hylarana nigrovittata [Animal]
Gaegurin
127021
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal Mast cell degranulation Histamine releasing
PaperY. Ma et al. / Genomics 95 (2010) 66-71. Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0415307 VERIFIED: YES
Provenance & Taxonomy
Rana nigrovittata [Animal]
Gaegurin
127021
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Candida albicans ATCC2002
2.34 μg/mL
MIC
PMID19778602 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19778602/
RECORD: Rec_0417738 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
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