Peptide Database

Peptide NameE3 ubiquitin-protein ligase MARCHF8

Function Ontology

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral budding inhibition

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Standard StatusStandard

Sequence Length291 amino acids

Chemical FormulaC1453H2285N397O432S23

DescriptionStandard

        MSMPLHQISAIPSQDAISARVYRSKTKEKEREEQNEKTLGHFMSHSSNISKAGSPPSASAPAPVSSFSRTSITPSSQDICRICHCEGDDESPLITPCHCTGSLHFVHQACLQQWIKSSDTRCCELCKYEFIMETKLKPLRKWEKLQMTSSERRKIMCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGQATGILEWPFWTKLVVVAIGFTGGLLFMYVQCKVYVQLWKRLKAYNRVIYVQNCPETSKKNIFEKSPLTEPNFENKHGYGICHSDTNSSCCTEPEDTGAEIIHV
    

Molecular Weight32964.58 Da

Isoelectric Point (pI)8.10

Net Charge (pH 7.0)3.34

Net Charge (pH 7.4) 2.25

Charge Density (pH 7.0) 0.0115

GRAVY Index-0.30

Hydrophobic Moment 0.68

Boman Index-0.01

Instability Index55.06

Aliphatic Index 75.36

Aromaticity 0.0825

Extinction Coeff. Reduced 44920.00

Extinction Coeff. Oxidized 45920.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0227566 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyMARCH

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other ModsPhosphorylation Ser253

Bio-Activity Profile

Function

Antiviral Entry inhibitor Release inhibition Budding inhibition Anti-HIV-1

TargetHuman immunodeficiency virus type 1(HIV-1)