Peptide Database

Peptide NameAla51 substitution mutant of Tat (49-57)

Function Ontology

Anticancer

Antimicrobial

Delivery / Targeting ▸ Cell penetration ▸ Cell-penetrating peptide

Delivery / Targeting ▸ Drug delivery vehicle

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC50H99N29O11

DescriptionStandard

        RKARRQRRR
    

Molecular Weight1282.51 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)6.76

Net Charge (pH 7.4) 6.55

Charge Density (pH 7.0) 0.7510

GRAVY Index-3.62

Hydrophobic Moment 0.78

Boman Index-1.88

Instability Index221.22

Aliphatic Index 11.11

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 736.63

LogP -9.73

H-bond Donors 30.0

H-bond Acceptors 18.0

Rotatable Bonds 48.0

Heavy Atoms 90.0

Ring Count 0.0

Amide Bonds 9.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0080533 VERIFIED: NO

Provenance & Taxonomy

OrganismHuman immunodeficiency virus 1 [Virus]

FamilyTat

Tax ID11676

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermFluorescein/FITC labeling

C-TermNone

Other ModsN-term detail: Labelled with fluorescein with aminohexanoic space

Bio-Activity Profile

Function

Cell-penetrating peptide

TargetJurkat

MethodFluorescence-based uptake assay

RECORD: Rec_0125780 VERIFIED: NO

Provenance & Taxonomy

OrganismProtein derived [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Termfluorescein with 6-aminohexanoic acid (Ahx) spacer

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

RECORD: Rec_0180418 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermLabelled with fluorescein with aminohexanoic space

C-TermNone

Bio-Activity Profile

Function

Drug Delivery Vehicle Cell-penetrating peptide

RECORD: Rec_0237217 VERIFIED: NO

Provenance & Taxonomy

OrganismProtein derived [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-Termfluorescein with 6-aminohexanoic acid (Ahx) spacer

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

RECORD: Rec_0339147 VERIFIED: NO

Provenance & Taxonomy

OrganismHuman immunodeficiency virus 1 [Virus]

FamilyTat

Tax ID11676

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermFluorescein/FITC labeling

C-TermNone

Bio-Activity Profile

Function

Cell-penetrating peptide Cargo delivery