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MYP_073743
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Basic Information
OH-CATH30
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
30 amino acids
C175H289N47O34
Standard
Sequence
KFFKKLKNSVKKRAKKFFKKPRVIGVSIPF
Physicochemical Analysis
3595.46 Da
12.00
11.75
11.53
0.3917
-0.52
0.76
-0.23
4.33
71.33
0.1667
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1357.19
-6.88
48.0
46.0
128.0
256.0
7.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0153144 VERIFIED: YES
Provenance & Taxonomy
Ophiophagus hannah [Animal]
Cathelicidin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Pseudomonas aeruginosa ATCC 27853
PaperIdentification and characterization of novel reptile cathelicidins from elapid snakes. Peptides. 2008 Oct;29(10):1685-1691. doi: 10.1016/j.peptides.2008.06.008. PMID: 18620012. | PubMed PMID: 22491685 PMID18620012;22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18620012/
RECORD: Rec_0158980 VERIFIED: YES
Provenance & Taxonomy
Ophiophagus hannah [Animal]
Cathelicidin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Escherichia coli ML-35p
3.125 μg/mL
MIC
PaperIdentification and characterization of novel reptile cathelicidins from elapid snakes. Peptides. 2008 Oct;29(10):1685-1691. doi: 10.1016/j.peptides.2008.06.008. PMID: 18620012. | PubMed PMID: 22491685 PMID18620012;22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18620012/
RECORD: Rec_0159551 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial
Escherichia coli ATCC 25922 or ML-35p or 6 clincal strains
1.56-12.5 μg/mL
MIC
PaperEfficacy of OH-CATH30 and its analogs against drug-resistant bacteria in vitro and in mouse models.
RECORD: Rec_0161633 VERIFIED: YES
Provenance & Taxonomy
Ophiophagus hannah [Animal]
Cathelicidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
E. cloacae ATCC 13047
25 μg/mL
MIC
PMID22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22491685/
RECORD: Rec_0165142 VERIFIED: YES
Provenance & Taxonomy
Ophiophagus hannah [Animal]
Cathelicidin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Hemolytic
human red blood cells
PaperIdentification and characterization of novel reptile cathelicidins from elapid snakes. Peptides. 2008 Oct;29(10):1685-1691. doi: 10.1016/j.peptides.2008.06.008. PMID: 18620012. | PubMed PMID: 22491685 PMID18620012;22491685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18620012/
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