Peptide Database

Peptide NameMargatoxin

Function Ontology

Annotation / Sequence feature ▸ Nuclear export signal

Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity

Membrane / Ion-channel modulation ▸ Ion channel inhibition

Membrane / Ion-channel modulation ▸ Potassium channel modulation ▸ Potassium channel inhibitor

Venom / Toxin ▸ General toxin ▸ Toxin

Venom / Toxin ▸ Toxin

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC178H292N52O50S7

DescriptionStandard

        TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
    

Molecular Weight4185.00 Da

Isoelectric Point (pI)9.27

Net Charge (pH 7.0)5.42

Net Charge (pH 7.4) 5.08

Charge Density (pH 7.0) 0.1389

GRAVY Index-0.36

Hydrophobic Moment 0.28

Boman Index-0.04

Instability Index58.29

Aliphatic Index 45.13

Aromaticity 0.0513

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1635.36

LogP -19.85

H-bond Donors 59.0

H-bond Acceptors 64.0

Rotatable Bonds 136.0

Heavy Atoms 287.0

Ring Count 7.0

Amide Bonds 43.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0177158 VERIFIED: NO

Provenance & Taxonomy

OrganismCentruroides margaritatus [Animal]

Structure & Mods

Configlinear disulfide-stabilized peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-29, 13-34, 17-36

Bio-Activity Profile

Function

Toxin

TargetKv1

RECORD: Rec_0393088 VERIFIED: YES

Provenance & Taxonomy

OrganismCentruroides margaritatus [Animal]

FamilyPotassium channel inhibitor family

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide7-29; 13-34; 17-36

Bio-Activity Profile

Function

Toxin Venom Potassium channel inhibitor family Ion channel inhibitor Pathogenesis-associated Host defense