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MYP_073728
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Standard
38 amino acids
C178H281N65O48S6
Standard
Sequence
GFGCPFNQGACHRHCRSIRRRGGYCAGLIKQTCTCYRN
Physicochemical Analysis
4291.93 Da
9.69
6.87
6.48
0.1808
-0.61
0.82
-0.22
92.72
36.05
0.1053
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1859.52
-24.55
74.0
63.0
139.0
297.0
7.0
41.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0128475 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial
PaperCAMP: Collection of sequences and structures of antimicrobial peptides PMID24265220 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24265220/
RECORD: Rec_0151764 VERIFIED: YES
Provenance & Taxonomy
Rhipicephalus minuscule [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
APD analysis reveals that this sequence is similar (94.74%) to AaDfsin defensin C=R=G: 16%. GRAVY: -0.61; mol Wt: 4291.996; mol formula: C178H283N63O48S6; mol ex coeff: 3355. Chemical modification: 3 disulfide bonds
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus
0.33-1.33 μM
MIC
PaperNovel structural determinants and bacterial death-related regulatory effects of the scorpion defensin BmKDfsin4 against gram-positive bacteria PMID39488304 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/39488304/
RECORD: Rec_0172256 VERIFIED: NO
Provenance & Taxonomy
Boophilus microplus [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
4-25; 11-33; 15-35
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0242039 VERIFIED: YES
Provenance & Taxonomy
Rhipicephalus microplus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0301036 VERIFIED: YES
Provenance & Taxonomy
Boophilus microplus [Animal]
Defensin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperPubMed PMID: 14642886 PMID14642886 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/14642886/
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