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MYP_073659
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Standard
32 amino acids
C148H252N40O42S4
Standard
Sequence
GILDTFKGVAKGVAKDLAVHMLENLKCKMTGC
Physicochemical Analysis
3392.09 Da
8.79
1.83
1.53
0.0571
0.30
0.60
0.14
6.19
97.50
0.0312
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1319.65
-11.12
47.0
49.0
119.0
234.0
2.0
32.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0194083 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Gram- negative bacterium
50 μM
MIC
RECORD: Rec_0250777 VERIFIED: YES
Provenance & Taxonomy
Rana luteiventris [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0259857 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-32
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
100.0 μM
HC50
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/
RECORD: Rec_0292882 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-32
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
50.0 μM
MIC
PaperJ.M. Conlon et al. / Developmental and Comparative Immunology 35 (2011) 644-649. Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/
RECORD: Rec_0312102 VERIFIED: YES
Provenance & Taxonomy
Rana pretiosa [Animal]
Ranatuerin
Structure & Mods
Single-chain peptide backbone represented as a linear sequence entry [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25726
50 μM
MIC
PMID21295070 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21295070/
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