Peptide Database

Peptide NameSLAY-screened peptide P1845

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length17 amino acids

Chemical FormulaC74H123N21O27S

DescriptionStandard

        SALAVVTSRTSCTYTPN
    

Molecular Weight1770.96 Da

Isoelectric Point (pI)7.94

Net Charge (pH 7.0)0.45

Net Charge (pH 7.4) 0.23

Charge Density (pH 7.0) 0.0264

GRAVY Index0.13

Hydrophobic Moment 0.22

Boman Index0.06

Instability Index49.11

Aliphatic Index 68.82

Aromaticity 0.0588

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 786.96

LogP -12.42

H-bond Donors 30.0

H-bond Acceptors 29.0

Rotatable Bonds 52.0

Heavy Atoms 123.0

Ring Count 2.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0063553 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/