Peptide Database

Peptide Nameamphiregulin

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length84 amino acids

Chemical FormulaC414H676N134O128S6

DescriptionStandard

        SVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEK
    

Molecular Weight9771.01 Da

Isoelectric Point (pI)9.53

Net Charge (pH 7.0)9.59

Net Charge (pH 7.4) 9.15

Charge Density (pH 7.0) 0.1141

GRAVY Index-1.56

Hydrophobic Moment 0.51

Boman Index-0.46

Instability Index36.97

Aliphatic Index 33.57

Aromaticity 0.0595

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4394.83

LogP -53.87

H-bond Donors 154.0

H-bond Acceptors 146.0

Rotatable Bonds 347.0

Heavy Atoms 682.0

Ring Count 11.0

Amide Bonds 96.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0168652 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsN-linked glycosylation of asparagine residue at position 19; predicted N-linked glycosylation of asparagine at position 113. Predicted disulphide bond formation between cysteine resdiues at positions 46 and 59, 54 and 70, and 72 and 81

Bio-Activity Profile

Function

Immunomodulatory Signaling peptide

Targetepidermal growth factor receptor (Human)