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MYP_073520
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiparasitic ▸ Anthelminthic
Antiparasitic ▸ Anthelminthic ▸ Nematicidal activity
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
30 amino acids
C131H214N36O39S6
Standard
Sequence
GIPCGESCVFIPCITGAIGCSCKSKVCYRN
Physicochemical Analysis
3109.71 Da
8.33
1.70
1.40
0.0567
0.58
0.30
0.20
13.00
74.67
0.0667
1490.00
1865.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1185.12
-14.10
47.0
47.0
98.0
212.0
4.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0194231 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Immunomodulatory Nematocidal Anthelmintic Hemolytic Anti-Gram-positive
Enterococcus faecalis
100 μM
MIC
PaperGene coevolution and regulation lock cyclic plant defence peptides to their targets | PubMed PMID 21596750 | Gilding et al., 2016 PMID21596750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596750/
RECORD: Rec_0200815 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Immunomodulatory Nematocidal Anthelmintic Hemolytic
Human cervical carcinoma HeLa
0.6 μM
IC50
PaperGene coevolution and regulation lock cyclic plant defence peptides to their targets | PubMed PMID 21596750 | Gilding et al., 2016 PMID21596750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596750/
RECORD: Rec_0210805 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Antimicrobial Antibacterial Anticancer Cytotoxic Immunomodulatory Nematocidal Anthelmintic Hemolytic Anti-Gram-negative
Escherichia coli
1.1 μM
MIC
PaperGene coevolution and regulation lock cyclic plant defence peptides to their targets | PubMed PMID 21596750 | Gilding et al., 2016 PMID21596750 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596750/
RECORD: Rec_0212799 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
4-20, 8-22, 13-27
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Anticancer Hemolytic
PMID21596752 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21596752/
RECORD: Rec_0226532 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic cyclotide [Cyclic]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anticancer
Pseudomonas aeruginosa
4.7 μM
MIC
PaperDiscovery and characterization of novel cyclotides originated from chimeric precursors consisting of albumin-1 chain a and cyclotide domains in the fabaceae family
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