Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length169 amino acids

Chemical FormulaC877H1302N190O252S9

DescriptionStandard

        QGIVYPAGNCSGPPYVAAPFTIPDQSDSMLYLAFSEYFFQTSSFAYYTAGAFNITIAEEVIFYLFFFFFLQTCSYFNISTEIFGSIIPEVAKYSVTPYPVMLKLMATEIPIISLEQDSFTVEIQGSMEVFAVLPDSTPQSLFTMNIAANTSIALNIFDQKLMGSLCLNR
    

Molecular Weight18827.42 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-10.25

Net Charge (pH 7.4) -10.54

Charge Density (pH 7.0) -0.0607

GRAVY Index0.48

Hydrophobic Moment 0.55

Boman Index0.32

Instability Index51.76

Aliphatic Index 90.65

Aromaticity 0.1657

Extinction Coeff. Reduced 14900.00

Extinction Coeff. Oxidized 15025.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 6952.91

LogP -59.65

H-bond Donors 236.0

H-bond Acceptors 251.0

Rotatable Bonds 590.0

Heavy Atoms 1328.0

Ring Count 39.0

Amide Bonds 183.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0382426 VERIFIED: NO

Provenance & Taxonomy

OrganismEudyptes filholi [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence