Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length474 amino acids

Chemical FormulaC2377H3782N608O668S19

DescriptionStandard

        DKGEKMLKTWYSFLLCWLSMQLEANPGLKVRITQKGLDYGRRIGMELLKQAVLKETFPSWSGQESFSVVKVNYVISRLRINAVDFPETSASFIPGTGISLSVAHASATISADWRMNTWLLKDQGGITVSISGLFIAVIFKVSRDSTGRLSMLLHNCQLSIGSVKVKLNGGSSWIYSFLSGFLEKPIHTKLDENLCLNIKYKIQMMDAQLRKHKVLSQIDAFAQIDYSLVSSPAVFKSHINLDLKGTVYPVGNHTDPPFVPAPFALPNQGDSMLNLGVSSYFLKSASLAYYRAGAFNITISKELATTFNLNTTLFKDFVPEIALSYMTACPVLLKLMATSPPAVSLNADKCMLQITGCVEVFAVLPNSTTQYIFTGNLTASTRVNLTVTGQKLIISLLLKRLQLFLLHSTLGFCEEISVVENFLSNALQSAVIPVINDKLGKGFPLLNLAHTTLTGPVIKMNKGHLVISTDVHYK
    

Molecular Weight52174.36 Da

Isoelectric Point (pI)9.29

Net Charge (pH 7.0)13.58

Net Charge (pH 7.4) 12.66

Charge Density (pH 7.0) 0.0286

GRAVY Index0.23

Hydrophobic Moment 0.72

Boman Index0.17

Instability Index30.17

Aliphatic Index 105.91

Aromaticity 0.0907

Extinction Coeff. Reduced 52370.00

Extinction Coeff. Oxidized 52745.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007039 VERIFIED: NO

Provenance & Taxonomy

OrganismLeptosomus discolor [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria