Peptide Database

Peptide NameSLAY-screened peptide P4284

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC101H153N31O30S

DescriptionStandard

        AYHMAVLRQPSNDPYKHNAT
    

Molecular Weight2313.55 Da

Isoelectric Point (pI)8.55

Net Charge (pH 7.0)0.97

Net Charge (pH 7.4) 0.67

Charge Density (pH 7.0) 0.0484

GRAVY Index-1.04

Hydrophobic Moment 0.51

Boman Index-0.15

Instability Index72.20

Aliphatic Index 49.00

Aromaticity 0.1000

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 991.41

LogP -10.78

H-bond Donors 33.0

H-bond Acceptors 34.0

Rotatable Bonds 70.0

Heavy Atoms 163.0

Ring Count 6.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0346432 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/