Peptide Database

Peptide NameSLAY-screened peptide P4981

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC108H181N33O23S5

DescriptionStandard

        WRYMINPRALLCKMCKRACI
    

Molecular Weight2470.12 Da

Isoelectric Point (pI)9.89

Net Charge (pH 7.0)4.73

Net Charge (pH 7.4) 4.48

Charge Density (pH 7.0) 0.2364

GRAVY Index0.14

Hydrophobic Moment 0.48

Boman Index-0.10

Instability Index77.06

Aliphatic Index 88.00

Aromaticity 0.1000

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7115.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 924.28

LogP -4.77

H-bond Donors 37.0

H-bond Acceptors 33.0

Rotatable Bonds 81.0

Heavy Atoms 169.0

Ring Count 4.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0176262 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/