Peptide Database

Peptide NameSLAY-screened peptide P2635

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H159N29O29S2

DescriptionStandard

        QPRTSRYFCPHITCPYGFYY
    

Molecular Weight2499.82 Da

Isoelectric Point (pI)8.82

Net Charge (pH 7.0)1.82

Net Charge (pH 7.4) 1.53

Charge Density (pH 7.0) 0.0912

GRAVY Index-0.66

Hydrophobic Moment 0.58

Boman Index-0.02

Instability Index80.68

Aliphatic Index 19.50

Aromaticity 0.3000

Extinction Coeff. Reduced 5960.00

Extinction Coeff. Oxidized 6085.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 927.03

LogP -6.54

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 68.0

Heavy Atoms 177.0

Ring Count 10.0

Amide Bonds 20.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0165235 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/