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MYP_073276
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Basic Information
Fusaricidin A/LI-F04a 5
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
6 amino acids
C25H45N7O10
Standard
Sequence
TVVTNA
Physicochemical Analysis
603.67 Da
5.18
-0.60
-0.79
-0.1003
0.88
0.41
0.32
-30.87
113.33
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
292.37
-4.21
10.0
10.0
17.0
42.0
0.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0152774 VERIFIED: YES
Provenance & Taxonomy
Bacillus polymyxa [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Lipidation
Esterification
The carboxylic end of Ala6 forms an ester bond with the hydroxyl group of T1. Val2, Asn5, Ala6 are D-amino acids and Thr4 is a D-allo-Thr. In addition, the N-terminus NH is lipidated with 15-guanidino-3-hydroxypentadecanoic acid (GHPD). Refer to the article for additional physical properties
Bio-Activity Profile
Antimicrobial Antifungal
fungi Fusarium oxysporum HF8801, Fusarium oxysporum HF8835, A. niger HUT 2016, A. oryzae 1FO 4214, and P. thomii
1.56-3.12 μg/mL
MIC
PaperFusaricidin A, a new depsipeptide antibiotic produced by Bacillus polymyxa KT-8. Taxonomy, fermentation, isolation, structure elucidation and biological activity
RECORD: Rec_0159635 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 33591
16 μg/mL
MIC
PMID22392790 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22392790/
RECORD: Rec_0173743 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0193129 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 700699 MU50
128 μg/mL
MIC
PMID22392790 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22392790/
RECORD: Rec_0204638 VERIFIED: YES
Provenance & Taxonomy
Bacillus polymyxa [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal
Gram-positive
PaperPubMed PMID: 8621351 | PubMed PMID: 23185515 PMID8621351;23185515 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8621351/
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