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MYP_073174
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Basic Information
S8
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
11 amino acids
C81H119N17O12
Standard
Sequence
KKKFFFFFKKK
Physicochemical Analysis
1522.92 Da
10.70
5.75
5.54
0.5231
-0.85
0.27
-0.28
-4.57
0.00
0.4545
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
510.44
1.23
18.0
18.0
55.0
110.0
5.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064298 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Human histiocytic lymphoma U-937
64 μM
LD50
PMID25192319 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25192319/
RECORD: Rec_0071862 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: U-937
64 μM
LD50
PaperRational design of artificial beta-strand-forming antimicrobial peptides with biocompatible properties. Mol Pharm. 2014 Oct 6;11(10):3492-3502. doi: 10.1021/mp500271c. PMID: 25192319. PMID25192319 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25192319/
RECORD: Rec_0098071 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PaperRational design of artificial beta-strand-forming antimicrobial peptides with biocompatible properties. Mol Pharm. 2014 Oct 6;11(10):3492-3502. doi: 10.1021/mp500271c. PMID: 25192319. PMID25192319 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25192319/
RECORD: Rec_0166831 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli DH5alpha
16 μM
MIC
PMID25192319 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25192319/
RECORD: Rec_0273941 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
stereochemistry not specified [Other]
Bio-Activity Profile
Anticancer
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