Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length288 amino acids

Chemical FormulaC1427H2275N359O413S18

DescriptionStandard

        ICKTVVSGISNLEQNLQEISMTSKVDEFTEVDYTLVSPPDITAITMDMNCKGEFYSLAHRAEFPKPPPPMDLGASADRMLYFGLSQYLFNSAGFAYHTSDALKCVVNDQMLPKDAPLHLNISSLAIMMPKLRKMFPDLPVELLIASREPPSLFMAAGNLSLCVDAAVDVVAVWPNSSQAFLFSLDVNVSLTTKLTIDADKLHGILALDSFKISELKSAVGSVPVMAFQLGMKFISEKIVIPKVNGRLLKGIPLPMMKNVRLVNAQLLNKEVRSDFPGEFENNDKLFVG
    

Molecular Weight31645.65 Da

Isoelectric Point (pI)5.44

Net Charge (pH 7.0)-4.90

Net Charge (pH 7.4) -5.43

Charge Density (pH 7.0) -0.0170

GRAVY Index0.18

Hydrophobic Moment 0.61

Boman Index0.15

Instability Index26.85

Aliphatic Index 100.87

Aromaticity 0.0764

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 13200.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0042785 VERIFIED: NO

Provenance & Taxonomy

OrganismPetromyzon marinus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence