Peptide Database

Peptide NameNatriuretic peptide TNP-c

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC177H282N52O55S3

DescriptionStandard

        SDSKIGNGCFGFPLDRIGSVSGLGCNRIMQNPPKKFSGE
    

Molecular Weight4114.64 Da

Isoelectric Point (pI)8.84

Net Charge (pH 7.0)1.45

Net Charge (pH 7.4) 1.20

Charge Density (pH 7.0) 0.0371

GRAVY Index-0.42

Hydrophobic Moment 0.68

Boman Index-0.01

Instability Index9.81

Aliphatic Index 57.44

Aromaticity 0.0769

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1730.02

LogP -22.43

H-bond Donors 60.0

H-bond Acceptors 60.0

Rotatable Bonds 137.0

Heavy Atoms 287.0

Ring Count 6.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0013349 VERIFIED: YES

Provenance & Taxonomy

OrganismOxyuranus scutellatus canni [Animal]

FamilyNatriuretic peptide TNP

Tax ID183720

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-25

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Targetpre-contracted aortae by activating the natriuretic peptide receptor

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0075050 VERIFIED: YES

Provenance & Taxonomy

OrganismOxyuranus microlepidotus [Animal]

FamilyPeptide TNP

Tax ID111177

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-25

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Targetpre-contracted aortae by activating the natriuretic peptide receptor

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0120165 VERIFIED: NO

Provenance & Taxonomy

OrganismOxyuranus microlepidotus [Animal]; Oxyuranus scutellatus scutellatus [Animal]; Oxyuranus scutellatus canni [Animal]

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-25

Bio-Activity Profile

Function

Neuropeptide

RECORD: Rec_0159156 VERIFIED: YES

Provenance & Taxonomy

OrganismOxyuranus scutellatus canni [Animal]

FamilyNatriuretic peptide TNP

Tax ID183720

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide9-25

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour