Peptide Database

Peptide NameMTSC20EK

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Standard StatusStandard

Sequence Length22 amino acids

Chemical FormulaC132H205N29O40S

DescriptionStandard

        MTWEEWDKKIEEYTKKIEELIK
    

Molecular Weight2870.28 Da

Isoelectric Point (pI)4.82

Net Charge (pH 7.0)-2.49

Net Charge (pH 7.4) -2.72

Charge Density (pH 7.0) -0.1131

GRAVY Index-1.33

Hydrophobic Moment 0.67

Boman Index-0.24

Instability Index59.68

Aliphatic Index 70.91

Aromaticity 0.1364

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1157.89

LogP -4.02

H-bond Donors 40.0

H-bond Acceptors 39.0

Rotatable Bonds 102.0

Heavy Atoms 202.0

Ring Count 5.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0317292 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyFusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Fusion inhibition

TargetHIV-1 NL4-3 | TZM-bl cells

Activity0.0037±0.0005 μM

MethodIC50

Half-LifeMammalian: 30 h; Yeast: >20 h; E. coli: >10 h

PaperConserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors. | Geng X, Liu Z, Yu D, Qin B, Zhu Y, Cui S, Chong H, He Y. | Viruses. 2019 Jul 3;11(7):609. | DOI:10.3390/v11070609 | PMID:31277353 PMID31277353 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31277353/

RECORD: Rec_0376153 VERIFIED: YES