Peptide Database

Peptide Namemuscarinic toxin 3

Function Ontology

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Receptor modulation ▸ Antagonist

Neurological / Signaling ▸ Signaling peptide

Venom / Toxin ▸ General toxin ▸ Toxin-related activity

Standard StatusStandard

Sequence Length65 amino acids

Chemical FormulaC319H497N89O97S8

DescriptionStandard

        LTCVTKNTIFGITTENCPAGQNLCFKRWHYVIPRYTEITRGCAATCPIPENYDSIHCCKTDKCNE
    

Molecular Weight7387.42 Da

Isoelectric Point (pI)7.71

Net Charge (pH 7.0)0.87

Net Charge (pH 7.4) 0.42

Charge Density (pH 7.0) 0.0133

GRAVY Index-0.35

Hydrophobic Moment 0.70

Boman Index-0.03

Instability Index48.08

Aliphatic Index 61.54

Aromaticity 0.0923

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10470.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2998.82

LogP -32.71

H-bond Donors 111.0

H-bond Acceptors 108.0

Rotatable Bonds 234.0

Heavy Atoms 513.0

Ring Count 13.0

Amide Bonds 70.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0372241 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyGtoPdb peptide ligand

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsDisulphide bond formation between cysteine residues at positions 3 and 24, 17 and 42, 46 and 57 and 58 and 63

Bio-Activity Profile

Function

Receptor antagonist Toxin-related activity Signaling peptide

Targetα2A-adrenoceptor (Human); M1 receptor (Human); M2 receptor (Human)

Activity5 nM

MethodKi