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MYP_072907
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Basic Information
Linear Cyclotide Panitide L2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
28 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
XLPICGETCVLGRCYTPNCRCQYPICVR
Physicochemical Analysis
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0016755 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Cytotoxic
Human cervical carcinoma HeLa
6 μM
IC50
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0044283 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Animal]
Cyclotide
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=PYA (Pyroglutamic acid)
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0054729 VERIFIED: YES
Provenance & Taxonomy
Panicum laxum [Plant]
Cyclotide
Structure & Mods
backbone-cyclized peptide [Cyclic]
canonical L-amino-acid peptide [L]
Pyroglutamate
5-19, 9-21, 14-26.
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
2.5 μM
MIC
RECORD: Rec_0055153 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Plant]
Cyclotide
Structure & Mods
linear cyclotide scaffold [Linear]
ambiguous/noncanonical residue annotation [Modified]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
X at 1 (reported unspecified residue)
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
PaperDiscovery of linear cyclotides in monocot plant Panicum laxum of Poaceae family provides new insights into evolution and distribution of cyclotides in plants PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
RECORD: Rec_0119941 VERIFIED: YES
Provenance & Taxonomy
Steinchisma laxum [Animal]
Cyclotide
Structure & Mods
side-chain cyclized/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
X=PYA (Pyroglutamic acid)
Bio-Activity Profile
Antimicrobial Anticancer
Tumor cells: HeLa
6 μM
IC50
PMID23195955 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23195955/
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