Peptide Database

Peptide NameDrosophila defensin

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length40 amino acids

Chemical FormulaC188H292N58O53S6

DescriptionStandard

        ATCDLLSKWNWNHTACAAHCVTKGFKGGYCSDKAVCVCRR
    

Molecular Weight4405.08 Da

Isoelectric Point (pI)8.91

Net Charge (pH 7.0)3.91

Net Charge (pH 7.4) 3.52

Charge Density (pH 7.0) 0.0977

GRAVY Index-0.15

Hydrophobic Moment 0.52

Boman Index-0.03

Instability Index24.39

Aliphatic Index 53.75

Aromaticity 0.1000

Extinction Coeff. Reduced 12490.00

Extinction Coeff. Oxidized 12865.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1797.20

LogP -20.62

H-bond Donors 71.0

H-bond Acceptors 65.0

Rotatable Bonds 141.0

Heavy Atoms 305.0

Ring Count 8.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0015647 VERIFIED: YES

Provenance & Taxonomy

OrganismDrosophila elegans [Animal]

FamilyDefensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative

TargetEscherichia coli TOP10

MethodMex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)