Peptide Database

Peptide NameBMP-4

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Neurological / Signaling ▸ Receptor modulation ▸ Agonist

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length116 amino acids

Chemical FormulaC577H886N164O170S9

DescriptionStandard

        SPKHHSQRARKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
    

Molecular Weight13128.79 Da

Isoelectric Point (pI)7.60

Net Charge (pH 7.0)0.92

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0079

GRAVY Index-0.39

Hydrophobic Moment 0.56

Boman Index-0.02

Instability Index41.39

Aliphatic Index 73.88

Aromaticity 0.0948

Extinction Coeff. Reduced 19940.00

Extinction Coeff. Oxidized 20315.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 5355.34

LogP -55.43

H-bond Donors 189.0

H-bond Acceptors 186.0

Rotatable Bonds 421.0

Heavy Atoms 920.0

Ring Count 26.0

Amide Bonds 127.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0375389 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsThe active peptide is a homodimer linked by a disulphide bond between cysteine residues at position 80. Predicted N-linked glycosylation of asparagine residues at positions 58 and 73, and predicted disulphide bond formation between cysteine residues at positions 16 and 81, 45 and 113, and 49 and 115

Bio-Activity Profile

Function

Receptor agonist Immunomodulatory Signaling peptide

TargetBone morphogenetic protein receptors (Human)