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MYP_072372
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Basic Information
Piscidin 4
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral
Standard
44 amino acids
C235H360N80O63
Standard
Sequence
FFRHLFRGAKAIFRGARQGWRAHKVVSRYRNRDVPETDNNQEEP
Physicochemical Analysis
5313.87 Da
11.23
4.94
4.63
0.1123
-1.23
0.93
-0.38
39.54
46.59
0.1364
6990.00
6990.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2380.07
-24.70
85.0
70.0
175.0
378.0
11.0
48.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0200003 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
The native peptide has a modified amino acid at position 20 that, based upon mass spectrometry data, is probably a hydroxylated tryptophan. SAR: Synthetic piscidin 4 (with an unmodified tryptophan at position 20) has similar antibacterial activity to that of the native peptide
Bio-Activity Profile
Antimicrobial Antiparasitic
A-salmonicida
>37.54 μM
MIC
PaperPiscidin 4, a novel member of the piscidin family of antimicrobial peptides.
RECORD: Rec_0330238 VERIFIED: YES
Provenance & Taxonomy
Morone chrysops [Animal]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antiviral
PaperPubMed PMID: 19266617 PMID19266617 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19266617/
RECORD: Rec_0379817 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
The native peptide has a modified amino acid at position 20 that, based upon mass spectrometry data, is probably a hydroxylated tryptophan. SAR: Synthetic piscidin 4 (with an unmodified tryptophan at position 20) has similar antibacterial activity to that of the native peptide
Bio-Activity Profile
Antimicrobial Antiparasitic
L. garvieae
9.41 μM
MIC
PaperPiscidin 4, a novel member of the piscidin family of antimicrobial peptides.
RECORD: Rec_0425086 VERIFIED: YES
Provenance & Taxonomy
Morone saxatilis [Animal]
Structure & Mods
linear peptide [Linear]
mixed L/D amino-acid peptide [Mixed]
The native peptide has a modified amino acid at position 20 that, based upon mass spectrometry data, is probably a hydroxylated tryptophan. SAR: Synthetic piscidin 4 (with an unmodified tryptophan at position 20) has similar antibacterial activity to that of the native peptide
Bio-Activity Profile
Antimicrobial Antiparasitic
human pathogens Enterococcus faecalis
1.18 μM
MIC
PaperPiscidin 4, a novel member of the piscidin family of antimicrobial peptides.
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