Peptide Database

Peptide NameSLAY-screened peptide P452

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC106H159N33O25S

DescriptionStandard

        TAPRVAAPHTLHCNRWWLTP
    

Molecular Weight2327.67 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.56

Net Charge (pH 7.4) 1.26

Charge Density (pH 7.0) 0.0781

GRAVY Index-0.40

Hydrophobic Moment 0.23

Boman Index0.03

Instability Index56.03

Aliphatic Index 68.50

Aromaticity 0.1000

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 906.37

LogP -7.21

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 63.0

Heavy Atoms 165.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0058544 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/