Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length168 amino acids

Chemical FormulaC824H1324N226O245S7

DescriptionStandard

        MRLEMMFLWCVLVLVNLVSVATDTNAGDKVRLTQKGLEYGKIQVVNLGLPKSALRLVPGTGVMLSIDNAYINLRGNWRVKYFRFIRNSGTLDLSVSKLTVSTTIAITSDNTGRPMSPSVVILCPFAWIDEGSTPTQINEDSEALPEERSAYAAVSLWTTIGADHNHQR
    

Molecular Weight18541.15 Da

Isoelectric Point (pI)7.79

Net Charge (pH 7.0)0.67

Net Charge (pH 7.4) 0.30

Charge Density (pH 7.0) 0.0040

GRAVY Index0.05

Hydrophobic Moment 0.66

Boman Index0.09

Instability Index27.62

Aliphatic Index 101.49

Aromaticity 0.0714

Extinction Coeff. Reduced 27960.00

Extinction Coeff. Oxidized 28085.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 7567.25

LogP -78.78

H-bond Donors 267.0

H-bond Acceptors 255.0

Rotatable Bonds 608.0

Heavy Atoms 1302.0

Ring Count 25.0

Amide Bonds 181.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0326334 VERIFIED: NO

Provenance & Taxonomy

OrganismLabeo rohita [Bacterium]

FamilyBPI

Tax ID84645

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence