MYP_072292
Teixobactin
Antimicrobial
Standard
11 amino acids
C57H97N15O16
Standard
FISQIISTARI
1248.47 Da
9.75
0.76
0.56
0.0691
1.12
0.45
0.32
26.60
150.91
0.0909
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
520.00
-4.41
19.0
17.0
41.0
88.0
1.0
11.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0001036
VERIFIED: YES
Provenance & Taxonomy
Eleftheria terrae [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Esterification
A new peptide antibiotic has been discovered via a multichannel device, the iChip, to simultaneously isolate and grow uncultured bacteria. Structural characterization: An ester bond is formed between the backbone C-terminal Ile carboxylic acid and the side chain of Thr8. In addition, the N-terminal phe is methylated (XXM). There are 4 D-amino acids and enduracididine (represented with an Arg here)
Bio-Activity Profile
Antimicrobial
P-aeruginosa
>32 μg/mL
MIC
RECORD: Rec_0017349
VERIFIED: YES
Provenance & Taxonomy
Eleftheria terrae [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Esterification
A new peptide antibiotic has been discovered via a multichannel device, the iChip, to simultaneously isolate and grow uncultured bacteria. Structural characterization: An ester bond is formed between the backbone C-terminal Ile carboxylic acid and the side chain of Thr8. In addition, the N-terminal phe is methylated (XXM). There are 4 D-amino acids and enduracididine (represented with an Arg here)
Bio-Activity Profile
Antimicrobial
penicillin-resistant S. pneumoniae
<0.003 μg/mL
MIC
RECORD: Rec_0105465
VERIFIED: YES
Provenance & Taxonomy
Eleftheria terrae [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Esterification
A new peptide antibiotic has been discovered via a multichannel device, the iChip, to simultaneously isolate and grow uncultured bacteria. Structural characterization: An ester bond is formed between the backbone C-terminal Ile carboxylic acid and the side chain of Thr8. In addition, the N-terminal phe is methylated (XXM). There are 4 D-amino acids and enduracididine (represented with an Arg here)
Bio-Activity Profile
Antimicrobial
including Staphylococcus aureus MSSA or MRSA
0.25 μg/mL
MIC
RECORD: Rec_0176435
VERIFIED: YES
Provenance & Taxonomy
Eleftheria terrae [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Esterification
A new peptide antibiotic has been discovered via a multichannel device, the iChip, to simultaneously isolate and grow uncultured bacteria. Structural characterization: An ester bond is formed between the backbone C-terminal Ile carboxylic acid and the side chain of Thr8. In addition, the N-terminal phe is methylated (XXM). There are 4 D-amino acids and enduracididine (represented with an Arg here)
Bio-Activity Profile
Antimicrobial
M. catarrhalis
2 μg/mL
MIC
RECORD: Rec_0176964
VERIFIED: YES
Provenance & Taxonomy
Eleftheria terrae [Bacterium]
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Esterification
A new peptide antibiotic has been discovered via a multichannel device, the iChip, to simultaneously isolate and grow uncultured bacteria. Structural characterization: An ester bond is formed between the backbone C-terminal Ile carboxylic acid and the side chain of Thr8. In addition, the N-terminal phe is methylated (XXM). There are 4 D-amino acids and enduracididine (represented with an Arg here)
Bio-Activity Profile
Antimicrobial
H. influenzae
4 μg/mL
MIC
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