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MYP_072290
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Basic Information
Rantuerin-2csa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
32 amino acids
C145H254N38O41S2
Standard
Sequence
GILSSFKGVAKGVAKDLAGKLLETLKCKITGC
Physicochemical Analysis
3249.93 Da
9.51
3.74
3.50
0.1168
0.44
0.58
0.16
-4.20
112.81
0.0312
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1277.06
-11.76
47.0
47.0
116.0
226.0
1.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0163910 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Brevinin
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
10 μM
MIC
PMID18387372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18387372/
RECORD: Rec_0180572 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
27-32
Bio-Activity Profile
Antimicrobial
Staphylococcus aureus ATCC 25923
8 μM
MIC
PaperPeptide defenses of the cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group
RECORD: Rec_0182664 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Frog skin active peptide (FSAP); Ranatuerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative Anti-Gram-positive Hemolytic
Escherichia coli
PMID17451843;18387372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
RECORD: Rec_0205013 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
27-32
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
10.0 μM
MIC
PaperA.P. Subasinghage et al. / Biochimica et Biophysica Acta 1784 (2008) 924-929. Conformational analysis of the broad-spectrum antibacterial peptide, ranatuerin-2CSa: Identification of a full length helix-turn-helix motif
RECORD: Rec_0217314 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
27-32
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
PMID17451843;18387372 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
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