Peptide Database

Peptide NameSLAY-screened peptide P5393

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC117H150N28O32S2

DescriptionStandard

        PGYAWDTYYQHCSHSWKTYM
    

Molecular Weight2524.74 Da

Isoelectric Point (pI)7.26

Net Charge (pH 7.0)0.12

Net Charge (pH 7.4) -0.06

Charge Density (pH 7.0) 0.0060

GRAVY Index-1.16

Hydrophobic Moment 0.33

Boman Index0.01

Instability Index37.72

Aliphatic Index 5.00

Aromaticity 0.3000

Extinction Coeff. Reduced 16960.00

Extinction Coeff. Oxidized 16960.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 959.42

LogP -6.84

H-bond Donors 37.0

H-bond Acceptors 36.0

Rotatable Bonds 72.0

Heavy Atoms 179.0

Ring Count 11.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0255428 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/