Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length483 amino acids

Chemical FormulaC2432H3885N627O678S15

DescriptionStandard

        MARGPDDTWRWATLVVLAALGTAVTATTSPGIVARITQKGLDYACQQGVATLQKELEKVTIPTFSGSFKMKYLGKGKYTFYSLVIREFKLPNSQIRPLPGQDLDLSIKDASIKMSGKWKARKNFIKVSGNFDLSVEGISILAGLKLGYDPTSGHPTVTCSSCSSHINSVRVRISRSSLGWLIQLFRKKIESSLRNSMNRKICKVVTSTVSSKLQPYFQTLPVTTKIDNVAGIDYSLVAPPKATADNLDVLLKGEFFRLAHRGPPPFAPPALTLPNDHNRMVYLGISEYLFNTAGLVYQEAGVLHFTLSDDTLPKESKFLLTTKSFGTLLPQVAKMFPDMKMQLLIWASSPPNIAVCPTGLHLTFALDTQAVAVLPDSSLAPLFLLEMYVNVSVDIGTRSDRLVGELKLDKLLLELKHSDIGPFPVELLQTIMNYVVPTVVIPKINKKLQKGFPLPLPASIQLFNLVLQPHQDFLLFGADVRYS
    

Molecular Weight53236.63 Da

Isoelectric Point (pI)9.48

Net Charge (pH 7.0)16.16

Net Charge (pH 7.4) 15.36

Charge Density (pH 7.0) 0.0335

GRAVY Index0.08

Hydrophobic Moment 0.69

Boman Index0.12

Instability Index36.13

Aliphatic Index 102.71

Aromaticity 0.0849

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0102235 VERIFIED: NO

Provenance & Taxonomy

OrganismMonodon monoceros [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence