Peptide Database

Peptide NameSifuvirtide

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor

Standard StatusStandard

Sequence Length36 amino acids

Chemical FormulaC201H307N59O71

DescriptionStandard

        SWETWEREIENYTRQIYRILEESQEQQDRNERDLLE
    

Molecular Weight4685.94 Da

Isoelectric Point (pI)4.41

Net Charge (pH 7.0)-6.51

Net Charge (pH 7.4) -6.74

Charge Density (pH 7.0) -0.1808

GRAVY Index-1.79

Hydrophobic Moment 0.85

Boman Index-0.47

Instability Index69.24

Aliphatic Index 65.00

Aromaticity 0.1111

Extinction Coeff. Reduced 13980.00

Extinction Coeff. Oxidized 13980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2213.12

LogP -21.40

H-bond Donors 77.0

H-bond Acceptors 65.0

Rotatable Bonds 162.0

Heavy Atoms 331.0

Ring Count 6.0

Amide Bonds 41.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0006791 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHIV fusion inhibitor

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral Fusion inhibitor

TargetHIV-1 fusion inhibition assay

Activity0.0012±0.0002 μM

MethodIC50

RECORD: Rec_0023143 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3 PsV

RECORD: Rec_0079739 VERIFIED: YES

Provenance & Taxonomy

OrganismHuman immunodeficiency virus 1 [Virus]

Familygp41 fusion inhibitor

Tax ID11676

Structure & Mods

Configbranched peptide architecture [Branched]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other ModsTerminally acetylated/amidated therapeutic form

Bio-Activity Profile

Function

Antiviral Anti-HIV Fusion inhibitor Entry inhibitor

TargetHuman immunodeficiency virus 1

RECORD: Rec_0154312 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antiviral

TargetHIV-1 NL4-3

RECORD: Rec_0221145 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antiviral