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MYP_072039
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Basic Information
SFTI-SST-02
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
15 amino acids
C88H132N22O19S2
Standard
Sequence
CTKSIPPICRFWKTW
Physicochemical Analysis
1866.26 Da
9.50
2.74
2.50
0.1826
-0.18
0.72
0.04
31.97
52.00
0.2000
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
659.35
-2.88
26.0
24.0
54.0
131.0
7.0
14.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0133095 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
PC-3
100 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0198705 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer Cytotoxic
HUVEC
100 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0206930 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
Human red blood cells: no hemolytic activity(as show in Fig.4)
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0224199 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
HT-29
43.29±0.04 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/
RECORD: Rec_0405253 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
None
None
w=D-Tryptophane
Bio-Activity Profile
Antimicrobial Anticancer
MCF-7
55.13±0.07 μM
IC50
PaperDual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Sci Rep. 2016 Oct 13;6:35347. doi: 10.1038/srep35347. PMID: 27734947. PMID27734947 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27734947/