Peptide Database

Peptide NameSLAY-screened peptide P524

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC57H99N17O22S2

DescriptionStandard

        TLNATVNSCSVNCL
    

Molecular Weight1438.63 Da

Isoelectric Point (pI)5.18

Net Charge (pH 7.0)-0.62

Net Charge (pH 7.4) -0.84

Charge Density (pH 7.0) -0.0444

GRAVY Index0.66

Hydrophobic Moment 0.16

Boman Index0.19

Instability Index44.27

Aliphatic Index 104.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 651.81

LogP -10.64

H-bond Donors 24.0

H-bond Acceptors 24.0

Rotatable Bonds 45.0

Heavy Atoms 98.0

Ring Count 0.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0018428 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/