Peptide Database

Peptide Name6(derived from HCV C5A)

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Antiviral ▸ Virucidal activity

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC76H104N18O20S

DescriptionStandard

        SWLRDIWDWICE
    

Molecular Weight1621.81 Da

Isoelectric Point (pI)4.32

Net Charge (pH 7.0)-2.54

Net Charge (pH 7.4) -2.77

Charge Density (pH 7.0) -0.2116

GRAVY Index-0.27

Hydrophobic Moment 0.71

Boman Index0.11

Instability Index35.50

Aliphatic Index 97.50

Aromaticity 0.2500

Extinction Coeff. Reduced 16500.00

Extinction Coeff. Oxidized 16500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 624.82

LogP -0.96

H-bond Donors 24.0

H-bond Acceptors 19.0

Rotatable Bonds 48.0

Heavy Atoms 115.0

Ring Count 6.0

Amide Bonds 11.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0284735 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HCV Release inhibition

TargetHepatitis C virus (HCV) | Huh-7.5.1 cells

Activity27 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperA virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. | Cheng G, Montero A, Gastaminza P, Whitten-Bauer C, Wieland SF, Isogawa M, Fredericksen B, Selvarajah S, Gallay PA, Ghadiri MR, Chisari FV. | Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3088-93. | DOI:10.1073/pnas.0712380105 | PMID:18287023 PMID18287023 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18287023/

RECORD: Rec_0330716 VERIFIED: YES