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MYP_071872
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Basic Information
Temporin-1CSb
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Hormonal / Endocrine ▸ Hormone peptide
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
13 amino acids
C69H118N14O15
Standard
Sequence
FLPIIGKLLSGLL
Physicochemical Analysis
1383.76 Da
8.75
0.76
0.55
0.0584
1.82
0.47
0.67
10.98
210.00
0.0769
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
449.98
0.67
15.0
16.0
45.0
98.0
2.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0306709 VERIFIED: YES
Provenance & Taxonomy
Vespa magnifica [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
Escherichia coli ATCC 25922
30 μg/mL
MIC
Evidence URLhttps://www.uniprot.org/uniprotkb/A0SPI1/entry
RECORD: Rec_0332106 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
Human erythrocytes
95 μM
LD50
Paperhttps://pubmed.ncbi.nlm.nih.gov/17451843/ PMID17451843 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17451843/
RECORD: Rec_0338246 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
B. dysenteriae
20 μM
MIC
PaperPeptide defenses of the cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group
RECORD: Rec_0346869 VERIFIED: YES
Provenance & Taxonomy
Rana cascadae [Animal]
Temporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Gram-positive Enterococcus faecalis ATCC 29212
5 μM
MIC
PaperPeptide defenses of the cascades frog Rana cascadae: implications for the evolutionary history of frogs of the Amerana species group
RECORD: Rec_0372213 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Temporin
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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