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MYP_071786
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Basic Information
CPM
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
7 amino acids
C42H61N7O8S2
Standard
Sequence
CPFVFLM
Physicochemical Analysis
856.11 Da
5.52
-0.25
-0.47
-0.0357
2.34
0.09
0.80
63.60
97.14
0.2857
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
229.13
1.68
8.0
10.0
23.0
59.0
3.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0020065 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/
RECORD: Rec_0038464 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/
RECORD: Rec_0083100 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
cyclic peptide architecture [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
inhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells between H9/HIV-1IIIB cells and MT-2 cells
67.2±4.05 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperShort cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity. | Jia Q, Jiang X, Yu F, Qiu J, Kang X, Cai L, Li L, Shi W, Liu S, Jiang S, Liu K. | Bioorg Med Chem Lett. 2012 Apr 1;22(7):2393-5. | DOI:10.1016/j.bmcl.2012.02.037 | PMID:22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/
RECORD: Rec_0118194 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
Bio-Activity Profile
Antimicrobial Antiviral
inhibition of cell-cell fusion between H9/HIV-1IIIB cells and MT-2 cells between H9/HIV-1IIIB cells and MT-2 cells
67.2±4.05 μM
IC50
PaperPubMed PMID: 22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/
RECORD: Rec_0247282 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of pseudovirus infection
5.95 μM
IC50
PaperPubMed PMID: 22406118 PMID22406118 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22406118/
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