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MYP_071732
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Basic Information
Maximin-H14
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antifungal
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Reproductive biology ▸ Contraceptive activity ▸ Spermicidal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
20 amino acids
C95H168N22O23
Standard
Sequence
ILGPVLGLVGEPLGGLIKKI
Physicochemical Analysis
1986.48 Da
8.59
0.76
0.55
0.0380
1.22
0.57
0.53
28.05
185.00
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
687.98
-1.42
22.0
24.0
66.0
140.0
2.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0059895 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
161274
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
Strong hemolytic activity
Hemolysis
PaperMaximin-H14 Evidence URLhttps://www.uniprot.org/uniprotkb/Q58T46/entry
RECORD: Rec_0074039 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin H
161274
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anticancer Antiviral Anti-HIV-1 Spermicidal
PaperR. Lai et al. / Peptides 23 (2002) 427-435. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima PMID11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11835991/
RECORD: Rec_0230921 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0324284 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Maximin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans
PaperVariety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification. Eur J Immunol. 2005 Apr;35(4):1220-1229. doi: 10.1002/eji.200425615. PMID: 15770703. | Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. Peptides. 2002 Mar;23(3):427-435. doi: 10.1016/S0196-9781(01)00641-6. PMID: 11835991. PMID15770703;11835991 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15770703/
RECORD: Rec_0340035 VERIFIED: YES
Provenance & Taxonomy
Bombina maxima [Animal]
Bombinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
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