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MYP_071651
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Basic Information
DN57wt
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-Dengue virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
28 amino acids
C158H221N37O39
Standard
Sequence
AWLVHTQWFLDLPLPWLPGADTQGSNWI
Physicochemical Analysis
3262.67 Da
4.20
-2.11
-2.35
-0.0755
0.07
0.30
0.35
14.85
101.07
0.1786
22000.00
22000.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1179.05
-4.54
39.0
38.0
92.0
234.0
13.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0077601 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
DENV-2
PMID20582308 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20582308/
RECORD: Rec_0143795 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 14.3%, E 0.0%, T 39.3%, C 46.4% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0158275 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Dengue virus(DENV)
PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0163642 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-DENV Fusion inhibition
Dengue virus (DENV) | epithelial cells
30.6 μM
% inhibition
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPeptide derivatives as inhibitors of NS2B-NS3 protease from Dengue, West Nile, and Zika flaviviruses. | da Silva-Júnior EF, de Araújo-Júnior JX. | Bioorg Med Chem. 2019 Sep 15;27(18):3963-3978. | DOI:10.1016/j.bmc.2019.07.038 | PMID:31351847 PMID31351847 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/31351847/
RECORD: Rec_0282877 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
West Nile virus (Virus entry); LLC-MK2
7 %
Plaque assay
PaperPeptide inhibitors of dengue virus and West Nile virus infectivity. | Hrobowski YM, Garry RF, Michael SF. | Virol J. 2005 | PMID:15927084 PMID15927084 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15927084/