Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length536 amino acids

Chemical FormulaC2715H4304N706O752S19

DescriptionStandard

        MPTQVRRVLCFIPRRKTTSLSCSPDLHFHSCLLYRSLVPLQDLEVLAALQDEDMARGPGSARRWAALVVLVALGTAVTTTTNPGIVARVTQKGLDYACQQGVLTLQKELEKITIPTFSGNFKIKYLGKGQYSFFSMVIQGFNLPNSQIRPLPDEGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISILAALSLGYDPDSGHSTVTCPRCSSHINTVRIRISGSSVGWLIQLFHKRIESSLQNSMTSKICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRVTADNLDGLLKGEFFSLAHRSPPPFAPPALAFPTDHDRMVYLGISEYFFNTAGFVYQKAGALNLTLRDDMIPKESMFHLTTKFFGTLIPQVAKMFPDMQMQLFIWASLPPKLTVNPNGLNLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGARSDRLIGELRLDKLLLELKHSDVGPFSVELLQSVMNYAVPTIVLPVINKKLQRGFPLPLPAYIKLFNLILQPYQDFLLFGADVHYS
    

Molecular Weight59476.73 Da

Isoelectric Point (pI)9.20

Net Charge (pH 7.0)11.33

Net Charge (pH 7.4) 10.40

Charge Density (pH 7.0) 0.0211

GRAVY Index0.13

Hydrophobic Moment 0.79

Boman Index0.13

Instability Index37.21

Aliphatic Index 104.20

Aromaticity 0.0914

Extinction Coeff. Reduced 42860.00

Extinction Coeff. Oxidized 43235.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0060213 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

FamilyBPI/LBP

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria