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MYP_071617
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Basic Information
Opistoporin-1 (OP1; Non-disulfide-bridged peptide 3.5; Opistoporin-3, OP3; Arthropods, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
44 amino acids
C220H357N59O63
Standard
Sequence
GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS
Physicochemical Analysis
4836.55 Da
9.78
3.76
3.54
0.0855
-0.52
0.62
-0.03
19.38
86.59
0.0682
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1995.51
-18.22
68.0
67.0
163.0
342.0
8.0
47.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0365284 VERIFIED: YES
Provenance & Taxonomy
Opistophthalmus carinatus [Animal]
Opistoporin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
PaperEur J Biochem. 2002 Oct;269(19):4799-810. | http://www.ncbi.nlm.nih.gov/pubmed/12354111 PMID12354111 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12354111/
RECORD: Rec_0366288 VERIFIED: YES
Provenance & Taxonomy
Opistophthalmus carinatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
N. asteroides ATCC 3308
50
MIC
PMID12354111 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12354111/
RECORD: Rec_0369056 VERIFIED: YES
Provenance & Taxonomy
Opistophthalmus carinatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Enterococcus faecalis ATCC 19433
12.5 μM
MIC
PMID12354111;12457879;14575699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12354111/
RECORD: Rec_0380257 VERIFIED: YES
Provenance & Taxonomy
Opistophthalmus carinatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Saccharomyces cerevisiae
2 μM
IC50
PMID12354111;12457879;14575699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12354111/
RECORD: Rec_0381173 VERIFIED: YES
Provenance & Taxonomy
Opistophthalmus carinatus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Escherichia coli ATCC 25922
12.5 μM
MIC
PMID12354111;12457879;14575699 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12354111/
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